Voxeldoes: a computer program for 3-D dose calculation in therapeutic nuclear medicine.
Identifieur interne : 003163 ( Main/Exploration ); précédent : 003162; suivant : 003164Voxeldoes: a computer program for 3-D dose calculation in therapeutic nuclear medicine.
Auteurs : RBID : pubmed:12674095English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Indium Radioisotopes.
- radiotherapy : Neoplasms.
- Humans, Phantoms, Imaging, Radiotherapy Dosage, Software.
Abstract
A computer program, VoxelDose, was developed to calculate patient specific 3-D-dose maps at the voxel level. The 3-D dose map is derived in three steps: (i) The SPECT acquisitions are reconstructed using a filtered back projection method, with correction for attenuation and scatter; (ii) the 3-D cumulated activity map is generated by integrating the SPECT data; and (iii) a 3-D dose map is computed by convolution (using the Fourier Transform) of the cumulated activity map and corresponding MIRD voxel S values. To validate the VoxelDose software, a Liqui-Phil abdominal phantom with four simulated organ inserts and one spherical tumor (radius 4.2 cm) was filled with known activity concentrations of 111In. Four cylindrical calibration tubes (from 3.7 to 102 kBq/mL) were placed on the phantom. Thermoluminescent mini-dosimeters (mini-TLDs) were positioned on the surface of the organ inserts. Percent differences between the known and measured activity concentrations were determined to be 12.1 (tumor), 1.8 (spleen), 1.4, 8.1 (right and left kidneys), and 38.2% (liver), leading to percent differences between the calculated and TLD measured doses of 41, 16, 3, 5, and 62%. Large differences between the measured and calculated dose in the tumor and the liver may be attributed to several reasons, such as the difficulty in precisely associating the position of the TLD to a voxel and limits of the quantification method (mainly the scatter correction and partial volume effect). Further investigations should be performed to better understand the impact of each effect on the results and to improve absolute quantification. For all other organs, activity concentration measurements and dose calculations agree well with the known activity concentrations.
DOI: 10.1089/108497803321269386
PubMed: 12674095
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Voxeldoes: a computer program for 3-D dose calculation in therapeutic nuclear medicine.</title><author><name sortKey="Gardin, Isabelle" uniqKey="Gardin I">Isabelle Gardin</name><affiliation wicri:level="1"><nlm:affiliation>CHB, CHU, Laboratoire Universitaire QUANT.I.F., Rouen, France. isabelle.gardin@rouen.fnclcc.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CHB, CHU, Laboratoire Universitaire QUANT.I.F., Rouen</wicri:regionArea><placeName><region type="région">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Bouchet, Lionel G" uniqKey="Bouchet L">Lionel G Bouchet</name></author><author><name sortKey="Assie, Karine" uniqKey="Assie K">Karine Assié</name></author><author><name sortKey="Caron, Jerome" uniqKey="Caron J">Jerome Caron</name></author><author><name sortKey="Lisbona, Albert" uniqKey="Lisbona A">Albert Lisbona</name></author><author><name sortKey="Ferrer, Ludovic" uniqKey="Ferrer L">Ludovic Ferrer</name></author><author><name sortKey="Bolch, Wesley E" uniqKey="Bolch W">Wesley E Bolch</name></author><author><name sortKey="Vera, Pierre" uniqKey="Vera P">Pierre Vera</name></author></titleStmt><publicationStmt><date when="2003">2003</date><idno type="RBID">pubmed:12674095</idno><idno type="pmid">12674095</idno><idno type="doi">10.1089/108497803321269386</idno><idno type="wicri:Area/Main/Corpus">003525</idno><idno type="wicri:Area/Main/Curation">003525</idno><idno type="wicri:Area/Main/Exploration">003163</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Indium Radioisotopes (therapeutic use)</term><term>Neoplasms (radiotherapy)</term><term>Phantoms, Imaging</term><term>Radiotherapy Dosage</term><term>Software</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Phantoms, Imaging</term><term>Radiotherapy Dosage</term><term>Software</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A computer program, VoxelDose, was developed to calculate patient specific 3-D-dose maps at the voxel level. The 3-D dose map is derived in three steps: (i) The SPECT acquisitions are reconstructed using a filtered back projection method, with correction for attenuation and scatter; (ii) the 3-D cumulated activity map is generated by integrating the SPECT data; and (iii) a 3-D dose map is computed by convolution (using the Fourier Transform) of the cumulated activity map and corresponding MIRD voxel S values. To validate the VoxelDose software, a Liqui-Phil abdominal phantom with four simulated organ inserts and one spherical tumor (radius 4.2 cm) was filled with known activity concentrations of 111In. Four cylindrical calibration tubes (from 3.7 to 102 kBq/mL) were placed on the phantom. Thermoluminescent mini-dosimeters (mini-TLDs) were positioned on the surface of the organ inserts. Percent differences between the known and measured activity concentrations were determined to be 12.1 (tumor), 1.8 (spleen), 1.4, 8.1 (right and left kidneys), and 38.2% (liver), leading to percent differences between the calculated and TLD measured doses of 41, 16, 3, 5, and 62%. Large differences between the measured and calculated dose in the tumor and the liver may be attributed to several reasons, such as the difficulty in precisely associating the position of the TLD to a voxel and limits of the quantification method (mainly the scatter correction and partial volume effect). Further investigations should be performed to better understand the impact of each effect on the results and to improve absolute quantification. For all other organs, activity concentration measurements and dose calculations agree well with the known activity concentrations.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12674095</PMID><DateCreated><Year>2003</Year><Month>04</Month><Day>02</Day></DateCreated><DateCompleted><Year>2003</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1084-9785</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>1</Issue><PubDate><Year>2003</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Cancer biotherapy & radiopharmaceuticals</Title><ISOAbbreviation>Cancer Biother. Radiopharm.</ISOAbbreviation></Journal><ArticleTitle>Voxeldoes: a computer program for 3-D dose calculation in therapeutic nuclear medicine.</ArticleTitle><Pagination><MedlinePgn>109-15</MedlinePgn></Pagination><Abstract><AbstractText>A computer program, VoxelDose, was developed to calculate patient specific 3-D-dose maps at the voxel level. The 3-D dose map is derived in three steps: (i) The SPECT acquisitions are reconstructed using a filtered back projection method, with correction for attenuation and scatter; (ii) the 3-D cumulated activity map is generated by integrating the SPECT data; and (iii) a 3-D dose map is computed by convolution (using the Fourier Transform) of the cumulated activity map and corresponding MIRD voxel S values. To validate the VoxelDose software, a Liqui-Phil abdominal phantom with four simulated organ inserts and one spherical tumor (radius 4.2 cm) was filled with known activity concentrations of 111In. Four cylindrical calibration tubes (from 3.7 to 102 kBq/mL) were placed on the phantom. Thermoluminescent mini-dosimeters (mini-TLDs) were positioned on the surface of the organ inserts. Percent differences between the known and measured activity concentrations were determined to be 12.1 (tumor), 1.8 (spleen), 1.4, 8.1 (right and left kidneys), and 38.2% (liver), leading to percent differences between the calculated and TLD measured doses of 41, 16, 3, 5, and 62%. Large differences between the measured and calculated dose in the tumor and the liver may be attributed to several reasons, such as the difficulty in precisely associating the position of the TLD to a voxel and limits of the quantification method (mainly the scatter correction and partial volume effect). Further investigations should be performed to better understand the impact of each effect on the results and to improve absolute quantification. For all other organs, activity concentration measurements and dose calculations agree well with the known activity concentrations.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gardin</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><Affiliation>CHB, CHU, Laboratoire Universitaire QUANT.I.F., Rouen, France. isabelle.gardin@rouen.fnclcc.fr</Affiliation></Author><Author ValidYN="Y"><LastName>Bouchet</LastName><ForeName>Lionel G</ForeName><Initials>LG</Initials></Author><Author ValidYN="Y"><LastName>Assié</LastName><ForeName>Karine</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Caron</LastName><ForeName>Jerome</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Lisbona</LastName><ForeName>Albert</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ferrer</LastName><ForeName>Ludovic</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Bolch</LastName><ForeName>Wesley E</ForeName><Initials>WE</Initials></Author><Author ValidYN="Y"><LastName>Vera</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Biother Radiopharm</MedlineTA><NlmUniqueID>9605408</NlmUniqueID><ISSNLinking>1084-9785</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Phantoms, Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Software</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>4</Month><Day>4</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>8</Month><Day>27</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>4</Month><Day>4</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12674095</ArticleId><ArticleId IdType="doi">10.1089/108497803321269386</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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